GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs1005224 | 1 | rs1981898 | chr14:76175565 | TTLL5 | chr14:76127621-76421421:+ | 0.36 | 4.8 | 5.87E-6 | Large artery stroke |
| THYM | cis | rs11723261 | 1 | rs1986557 | chr4:283118 | ZNF718 | chr4:53272-156488:+ | 0.52 | 5.94 | 4.59E-8 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs9815354 | 1 | rs1994157 | chr3:41897482 | ULK4 | chr3:41288091-42003660:- | 0.96 | 9.51 | 1.88E-15 | Diastolic blood pressure |
| THYM | cis | rs1577917 | 1 | rs1995688 | chr6:86632319 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs1999852 | chr6:86705738 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs7301826 | 1 | rs2001483 | chr12:131318645 | STX2 | chr12:131274149-131323811:- | 0.35 | 5.89 | 5.79E-8 | Plasma plasminogen activator levels |
| THYM | cis | rs4237643 | 1 | rs2006751 | chr11:43670501 | HSD17B12 | chr11:43702143-43878160:+ | -0.58 | -5.99 | 3.71E-8 | Forced vital capacity |
| THYM | cis | rs2143950 | 1 | rs2010648 | chr14:35604892 | KIAA0391 | chr14:35591776-35786673:+ | 0.35 | 4.67 | 9.73E-6 | Atopic dermatitis |
| THYM | cis | rs2143950 | 1 | rs2010648 | chr14:35604892 | PPP2R3C | chr14:35554679-35591679:- | 0.26 | 4.92 | 3.68E-6 | Atopic dermatitis |
| THYM | cis | rs6540731 | 1 | rs2012917 | chr1:212405771 | NEK2 | chr1:211836115-211848967:- | -0.16 | -4.42 | 2.59E-5 | Intelligence (childhood) |
| THYM | cis | rs9457247 | 1 | rs2013815 | chr6:167373812 | RNASET2 | chr6:167343008-167412795:- | 0.47 | 7.83 | 7.0E-12 | Crohn's disease |
| THYM | cis | rs2077224 | 1 | rs2015246 | chr11:62196312 | ASRGL1 | chr11:62104774-62160885:+ | -0.29 | -4.41 | 2.74E-5 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs911119 | 1 | rs2016161 | chr20:23621174 | CST9 | chr20:23583049-23586610:- | 0.48 | 4.46 | 2.27E-5 | Chronic kidney disease |
| THYM | cis | rs2028299 | 1 | rs2028299 | chr15:90374257 | AP3S2 | chr15:90373832-90456222:- | -0.42 | -4.83 | 5.23E-6 | Type 2 diabetes |
| THYM | cis | rs9876781 | 1 | rs2045554 | chr3:48494542 | TREX1 | chr3:48501186-48509043:+ | 0.28 | 4.29 | 4.29E-5 | Longevity |